International Clinical Research Centre (ICRC) of St. Anne’s University Hospital in Brno

The International Clinical Research Centre (ICRC) is a medical research centre focusing on finding new methods, technologies and medicaments for prevention, diagnostics and treatment of cardiovascular, neurological and selected oncological diseases and disorders. These are among the most widespread diseases and causes of death in modern society. Thanks to its innovative approach, proactive teams, cutting-edge technologies and international collaborations, FNUSA-ICRC has become a multidisciplinary center of excellence in translational medical research already few years after the official opening in 2011. The Centre is a part of St. Anne’s University Hospital in Brno (FNUSA).

RESEARCH

Clinical research aims primarily at translational medicine - the development of new technologies, methods, processes and pharmaceuticals enabling effective prevention, early diagnostics and individualised treatment of selected diseases and disorders. It is based on co-operation among experts in international multidisciplinary teams. FNUSA-ICRC currently has 30 research teams divided into 7 research sections:

  • Clinical Cardiology
  • Clinical Neurology
  • Oncology Research
  • Clinical Multidsciplinary Research
  • Biomolecular and Cellular Engineering
  • Translation Medicine
  • Joint Research Facilities

RESEARCH INFRASTRUCTURE

FNUSA-ICRC purchased approximately 1,000 new, often state-of-the art, pieces of equipment in 2012-2015 using EU and national grants. Infrastructure available for research includes for example:

  • Angiographic line for interventional cardiology
  • Optical coherence tomography
  • Electrophysiology laboratory
  • Stereotaxis magnetic catheter navigation technology for both preclinical and clinical research
  • Sleep medicine laboratory
  • Laboratories for measurement of highly sensitive biological signals
  • Acquisition and monitoring system for synchronized recording of various biological signals
  • Neurological “bi-plane” angiography unit
  • Automatic cell imaging system with high throughput
  • Cellular imaging laboratory
  • Laboratory of cellular separations and cultures
  • Laboratory for cytomics, proteomics and genomics
  • Flow cytometer and cell sorter, magnetic cell separator and automatic cell analyzer
  • Confocal laser scanning microscope and laser micro dissection microscope
  • Mass spectrometer and spectrophotometer
  • Magnetic resonance imaging technologies for preclinical and clinical research
  • Ultrasound systems for preclinical and clinical research
  • Clinical pharmacology unit equipped with fully-monitoring beds
  • CGMP facility for pharmaceutical and biopharmaceutical manufacturing

RESEARCH RESULTS

Research activities of ICRC started in mid-2011 and by late-2019 produced the following results:

  • Nearly 1,900 scientific publications, mostly in renowned international scientific journals
  • 3 already awarded patents and 5 further pending patent applications
  • 10 registered industrial or utility models of novel diagnostic or therapeutic devices
  • 15 international scientific awards such as the Young Investigator Award, the Best Innovation Award or the Novartis Discovery Award
  • The prestigious national “Czech Brain Award – the Kapsch Invention Award” for one of the research team leaders

INTERNATIONAL TEAM

FNUSA-ICRC has attracted researchers and students from Argentina, Austria, Germany, Hungary, Italy, Poland, Portugal, Slovakia, Slovenia and other countries to Brno with the aim to build international research teams. Approximately 20 % of employees come from abroad. Several international training projects for physicians, scientists, students and healthcare staff have run under FNUSA-ICRC. These include both short- and long-term study stays at prestigious foreign institutions and visits by foreign specialists to Brno to share their experience and participate in research projects. Foreign students of medicine, life sciences and biomedical engineering come to Brno for internships at ICRC.

ACADEMIC PARTNERS

ICRC co-operates with a number of renowned foreign institutions such as the Mayo Clinic, University of California San Diego, Yale Medical School (USA), Karolinska Institutet (Sweden), University of Calgary (Canada), University of South Florida (USA) and others. Prominent Czech institutions are involved as well. They include Masaryk University, Brno University of Technology, University of Veterinary and Pharmaceutical Sciences in Brno, the Institute of Biophysics and Institute of Scientific Instruments of the Academy of Sciences of the Czech Republic and others.

COLLABORATION WITH INDUSTRY

Collaboration with industrial partners including, in particular, pharmaceutical companies, contract research organisations (CROs) and manufacturers of medical technologies is also intense. FNUSA-ICRC performs clinical trials of new pharmaceuticals and medical devices and other projects of contract research for large multinational companies as well as small local start ups. Its teams perform 15-20 such projects every year. The centre also has several joint research grants with industrial partners financed from national and international grant schemes. Representatives of industry come to FNUSA-ICRC to deliver public lectures on their company´s research and the centre works with several medical device manufacturers on the development of their products. Steps are being taken to commercialise the first results of FNUSA-ICRC research.

 

  • International Clinical Research Center
    St. Anne´s University Hospital in Brno
    Pekařská 53, Brno 656 91, Czech Republic
    www.fnusa-icrc.org, icrc@fnusa.cz